has been developed with the aim of facilitating the identification of potential therapeutical targets in more than 150 organisms responsible for human infections. The list of human pathogens was obtained from "The Approved List od Biological Agents" provided by the Advisory Commettee on Dangerous Pathogens ACDP
TiPs currently contains 4071 candidate pathogen target structures thoroughly annotated with both sequence and functional information. Each pathogen target is associated with its predicted drug(s) and the structural details of the drug binding mode are also provided. TiPs makes it possible to easily compare the drug binding mode in the predicted target structure to the one observed in the original X-ray drug-target complex and visualise useful similarities and differences.
The database can be queried by organism name (genus or specie name), protein family or function (EC number, GO terms, Pfam), as well as by UniProt ID. The query returns a sortable table providing information about both known and predicted drug-target pairs and links to visualise specific information on the drug(s) (physicochemical properties, structure, indication, side effects), the target(s) (UniProt annotation and PDB structure(s)) and to visually analyse or download their 3D complexes.
If you use this database, please cite the following reference:
Lepore R, Tramontano A, Via A : TiPs: a database of therapeutic targets in pathogens and associated tools.
Bioinformatics. 2013 Jul 15;29(14):1821-2. doi: 10.1093/bioinformatics/btt289. Epub 2013 May 21.