Tabhu Tool for AntiBody HUmanisation.
Tabhu is a web server for antibody humanisation specifically designed to help researcher in each step of a humanisation experiment. It makes available to the user a set of tools to:
Select the suitable humane template;
Select the grafting region;
Predict the non-human and humanised antibody paratope;
Select the minimum set of back-mutations to retain the parental binding affinity;
Build the three-dimensional humanised antibody model and check its structure;
Users can download the final humanised antibody variant nucleotide sequence and three dimensional model directly from the summary page.